Toolkit
Transgenic Mouse Lines
The Allen Institute for Brain Science has generated a large collection of transgenic mouse lines for use in research. Driver lines enable access to genetically-identified cell classes and can be used in combination with reporter lines to visualize or modify diverse populations of cells. This suite of molecular tools is used in our research and lines are made available to the community via The Jackson Laboratory.
Characterization data legend: A full list of abbreviations is available at the bottom of this page. Phenotypic characterization of selected lines can be accessed below, by clicking on the colored circle corresponding to a mouse line and an experimental data modality code:
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Histology (purple): Gene expression data by in situ hybridization (ISH)
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Neuronal connectivity (green): Projectional maps
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In vivo activity (gold): Sensory-evoked calcium responsiveness
Driver lines
Reporter lines
Abbreviations: RCL, Rosa26 – CAG promoter – LoxP-STOP-LoxP. RCFL, Rosa26 – CAG promoter – FRT-STOP-FRT – LoxP-STOP-LoxP. RCRL, Rosa26 – CAG promoter – Rox-STOP-Rox – LoxP-STOP-LoxP. RCF, Rosa26 – CAG promoter – FRT-STOP-FRT. RCR, Rosa26 – CAG promoter – Rox-STOP-Rox. LSL, LoxP-STOP-LoxP. TITL, TIGRE – Insulators – TRE promoter – LoxP-STOP-LoxP. TIT, TIGRE – Insulators – TRE promoter. TIT2L, TIGRE – Insulators – TRE2 promoter – LoxP-STOP-LoxP. ICL, Insulators – CAG promoter – Lox2272-STOP2-Lox2272. ICR, Insulators – CAG promoter – Rox-STOP2-Rox. FnGF, FRT – nls-mNeonGreen – FRT. GC6f, GCaMP6f. GC6s, GCaMP6s. nT, nls-tdTomato. Syp, Synaptophysin. tdT, tdTomato. TPT, tdTomato-P2A-tTA2.
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